Environmental Protection Agency, Office of Pesticide Programs, Label Review Manual, Chapter 7: Precautionary Labeling. The highlighted boxes reflect the values in the "Acute Toxicity" section of this fact sheet. Minimal effects clearing in less than 24 hours Irritation persisting for more than 21 days 22 See the text boxes on Toxicity Classification and Acute oral LD 50 values were determined to be 97.4 mg/kg and 118.8 mg/kg in female and male mice, respectively, andġ48.1 mg/kg and 161.2 mg/kg in female and male rats, respectively.20,21 No information was available regarding toxicity of capsaicin to fish or other aquatic life. 8 Although birds have the TRPV1 receptor, it is notĪctivated by capsaicin. Modes of toxicity for non-target organisms are expected to be similar to those of targeted insects and mammals.Ĭapsaicin is considered toxic to honeybees and other beneficial insects.15 The TRPV1 receptor then releases sensory neuropeptides that trigger a 3 In mammals, capsaicinīinds to the TRPV1 vanilloid receptor. Capsaicin triggers the release of the neuropeptide P from the sensory nerve fibers of the C type.8 Capsaicin has also been shown to repel insects as well as kill them. In insects, capsaicin's toxicity appears to be through metabolic disruption, membrane damage, and nervous systemĭysfunction.Inhalation results in inflammation of pulmonary tissue and damage to respiratory cells.11,12 CapsaicinĪlso has been evaluated for treatment of some cancers. Researchers have studied capsaicin and its interaction with the TRVP1 receptor for use in pain management. In addition to its use as a pesticide, capsaicin is used in law enforcement and as an ingredient in cosmetics.select your state then click on the link for "State Products." To find a list of products containing capsaicin which are registered in your state, visit the website.The NPIC fact sheets on Signal Words and Inert or "Other" Ingredients. See the pesticide label on the product and refer to Toxicity of the active ingredient and other ingredients in the product. Signal words for products containing capsaicin may range from Caution to Danger.
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